Graduate Work

Creighton University

At Creighton University, I was introduced to the mechanics of the inner ear by Drs. David He and Richard Hallworth. Under their guidance, I learned the concepts of electromotility and mechanotransduction while developing methods to analyze changes to somatic motility of the outer hair cells under patch clamp. I soon delved into the somatic motility phenomenon of the inner ear and began to analyze the structure-function relationship of prestin. During this time, I also had my initial introduction into protein bioinformatics working on projects with Dr. Hesham Ali and his graduate student Kate Dempsey. Through this group of engineers, electrophysiologists and bioinformaticians, I was able to elucidate aspects of the structural importance of prestin, on which I based my dissertation, and contributed to eight manuscripts, two as first author.