Therapeutic Drug Monitoring (TDM)

Abacavir

Therapeutic Drug Monitoring

An important pharmacological aspect of any drug therapy is managing both the therapeutic and toxic levels of the bioavailable active substance in vivo. This therapeutic drug monitoring (TDM) becomes a crucial aspect of health management when drug therapies are required for extended periods of treatment and/or their is a narrow therapeutic window. TDM is used in the treatment of several diseases including epilepsy, physchosis and AIDS.

At Consolidated Laboratory Services (CLS), my work was focused on TDM for patients infected with HIV and other sexually transmitted diseases. Under the tutelage of Dr. Sonny Gunawan, I learned to develop several CLIA certified assays that measured the bioavailability of antiretrovirals using many aspects of clinical chemistry. By the end of my tenure, I had developed several single panel assays that multiplexed antiretrovirals used in standard HAART treatments using advanced detection methods including HPLC-MS.